Inform HER2 DUAL ISH Test

Inform HER2 DUAL ISH Test

Inform HER2 Dual ISH is used to assess the HER2-positive status of breast cancer cells. In the name of the test, ISH stands for "in situ hybridization."

In HER2 positive breast cancer due to over expressive abnormal genes, the cells generate a lot of HER2 protein. This protein send signals to the cancer cells to grow. It has been found that every fourth cancer is an HER2 positive cancer. Thus assessing and evaluating the HER2 status of the cancerous growth is vital to the treatment plan. HER2 positice cancer is treated by immune targeted therapy – herceptin and also with a Tykerp chemical (discussed in FISH section).

In the Inform HER2 Dual ISH test, a special stain/dye is used to colour the protein cells of the cancerous growth, which is then pathologically examined under the microscope. The testing can be done on tissue samples which have been stored in chemicals or in wax. The result of the Inform HER2 Dual ISH test concluded the HER2 status of the tumor growth. Giving a result as "HER2-positive" or "HER2-negative."

Different laboratories and pathologists have different measures of classifying a tissue sample as Her2 positive or negative due to which the test results may be read wrong, adversely affecting the treatment plan. This is usually a case in borderline tissue samples. Also it is quite possible that in the same cancerous growth some cells may be HER2 positive, while some HER2 negative.

The Inform HER2 Dual ISH test is known to comparatively give better and accurate conclusive results of HER2 status diagnosis for cancer tissue sample as compared to the IHC HER2 test. This test is easier to be undertaken as it is also is less expensive and does not require a special microscope as needed in the FISH HER2 test.

For patients with HER2 test results being negative or borderline, the patient should be aware of the type of test done. For borderline results (0 or 1+ is negative,3+ result is positive) like a reading of 2+ the patient should definitely ask for a more accurate and precise test like Inform HER2 Dual ISH test, the Spot-Light CISH test, or the FISH test.

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